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HighVia-A flexible live-cell high-content screening pipeline to assess cellular toxicity

Abstract:

High-content screening to monitor disease-modifying phenotypes upon small-molecule addition has become an essential component of many drug and target discovery platforms. One of the most common phenotypic approaches, especially in the field of oncology research, is the assessment of cell viability. However, frequently used viability readouts employing metabolic proxy assays based on homogeneous colorimetric/fluorescent reagents are one-dimensional, provide limited information, and can in many...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/2472555220923979

Authors


Publisher:
SAGE Publications
Journal:
SLAS DISCOVERY: Advancing the Science of Drug Discovery More from this journal
Article number:
ARTN 2472555220923979
Place of publication:
United States
Publication date:
2020-05-27
DOI:
EISSN:
2472-5560
ISSN:
2472-5552
Pmid:
32458721
Language:
English
Keywords:
Pubs id:
1107585
Local pid:
pubs:1107585
Deposit date:
2020-06-17

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