- Abstract:
-
BACKGROUND: Dysregulation of the complement system has been shown to play a major role in the pathogenesis of age-related macular degeneration (AMD). METHODS: The current evidence from human studies derives from immunohistochemical and proteomic studies in donor eyes, genetic association studies, and studies of blood complement protein levels. These lines of evidence are corroborated by in vitro and animal studies. RESULTS: In AMD donor eyes, detection of complement proteins in drusen sugges...
Expand abstract - Publisher copy:
- 10.1007/s00417-010-1568-6
-
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- Journal:
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
- Volume:
- 249
- Issue:
- 2
- Pages:
- 163-174
- Publication date:
- 2011-02-05
- DOI:
- EISSN:
-
1435-702X
- ISSN:
-
0721-832X
- URN:
-
uuid:6f3597d7-7997-4e3b-9426-ce7e616c52b1
- Source identifiers:
-
101544
- Local pid:
- pubs:101544
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application.
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