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Journal article

The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application.

Abstract:

BACKGROUND: Dysregulation of the complement system has been shown to play a major role in the pathogenesis of age-related macular degeneration (AMD). METHODS: The current evidence from human studies derives from immunohistochemical and proteomic studies in donor eyes, genetic association studies, and studies of blood complement protein levels. These lines of evidence are corroborated by in vitro and animal studies. RESULTS: In AMD donor eyes, detection of complement proteins in drusen sugges...

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Publisher copy:
10.1007/s00417-010-1568-6

Authors


Journal:
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Volume:
249
Issue:
2
Pages:
163-174
Publication date:
2011-02-05
DOI:
EISSN:
1435-702X
ISSN:
0721-832X
URN:
uuid:6f3597d7-7997-4e3b-9426-ce7e616c52b1
Source identifiers:
101544
Local pid:
pubs:101544

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