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Structural changes during ion channel gating

Abstract:

Ion channels are generally multi-subunit complexes, with the ion conduction pathway formed at the subunit interface. In moving between the closed and open states, three structurally distinct channels, represented by the recently determined structures of a mechanosensitive, ligand-gated and K(+) selective channel, all move transmembrane helices away from the central ion conduction pathway. In all three cases, this results in the displacement of a hydrophobic gate from the ion conduction pathwa...

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Authors


Doyle, Declan A More by this author
Journal:
Trends in Neurosciences
Volume:
27
Issue:
6
Pages:
298-302
Publication date:
2004
ISSN:
0166-2236
URN:
uuid:6f2a80a9-61ac-4f04-a605-628a3a50b59b
Local pid:
SGC:15165732

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