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Journal article

Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex

Abstract:

The mechanisms that regulate the switch between epidermal progenitor state and differentiation are not fully understood. Recent findings indicate that the chromatin remodelling BAF complex (Brg1-associated factor complex or SWI/SNF complex) and the transcription factor p63 mutually recruit one another to open chromatin during epidermal differentiation. Here, we identify a long non-coding transcript that includes an ultraconserved element, uc.291, which physically interacts with ACTL6A and mod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embr.201846734

Authors


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ORCID:
0000-0001-8723-9564
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ORCID:
0000-0001-6285-9927
Mancini, M More by this author
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Division:
MSD
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Role:
Depositor, Author
ORCID:
0000-0002-1575-8725
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO reports Journal website
Volume:
2020
Article number:
e46734
Publication date:
2020-02-04
Acceptance date:
2020-01-08
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Pmid:
32017402
Pubs id:
1086156
Local pid:
pubs:1086156
Language:
English
Keywords:
Format:
Print-Electronic

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