- Abstract:
-
Triggering receptor expressed on myeloid cells 2 (Trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia. However, the intracellular trafficking of Trem2 remains unclear. In this study, we showed that Trem2 in the plasma membrane underwent endocytosis and recycling. Trem2 is internalized in a clat...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1111/tra.12451
-
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- Grant:
- 973- 2012CB910701 and 2013DFA31990
- Grant:
- 2014- 2016
- Publisher:
- John Wiley & Sons Publisher's website
- Journal:
- Traffic Journal website
- Volume:
- 17
- Issue:
- 12
- Pages:
- 1286-1296
- Publication date:
- 2016-12-05
- DOI:
- EISSN:
-
1600-0854
- ISSN:
-
1398-9219
- Pubs id:
-
pubs:677387
- URN:
-
uri:6f26ebca-c3e8-4f08-8de3-f422974a8320
- UUID:
-
uuid:6f26ebca-c3e8-4f08-8de3-f422974a8320
- Local pid:
- pubs:677387
- Paper number:
- 12
- Copyright holder:
- John Wiley & Sons
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Journal article
Vps35-dependent recycling of Trem2 regulates microglial function
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+ National Basic Research Program
of China
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+ Crossdisciplinary
Collaborative Teams Program for
Science, Technology and Innovation
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Chinese Academy of Sciences
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