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Vps35-dependent recycling of Trem2 regulates microglial function

Abstract:

Triggering receptor expressed on myeloid cells 2 (Trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia. However, the intracellular trafficking of Trem2 remains unclear. In this study, we showed that Trem2 in the plasma membrane underwent endocytosis and recycling. Trem2 is internalized in a clat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/tra.12451

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Name:
Crossdisciplinary Collaborative Teams Program for Science, Technology and Innovation
Grant:
2014- 2016
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Name:
National Basic Research Program of China
Grant:
973- 2012CB910701
2013DFA31990
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Name:
National Science Foundation of China
Grant:
81125010,81030025
81600997
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Name:
Chinese Academy of Sciences
Publisher:
John Wiley & Sons
Journal:
Traffic More from this journal
Volume:
17
Issue:
12
Pages:
1286-1296
Publication date:
2016-12-01
Acceptance date:
2016-09-21
DOI:
EISSN:
1600-0854
ISSN:
1398-9219
Keywords:
Pubs id:
pubs:677387
UUID:
uuid:6f26ebca-c3e8-4f08-8de3-f422974a8320
Local pid:
pubs:677387
Source identifiers:
677387
Deposit date:
2017-02-08

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