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Journal article

Vps35-dependent recycling of Trem2 regulates microglial function

Abstract:

Triggering receptor expressed on myeloid cells 2 (Trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia. However, the intracellular trafficking of Trem2 remains unclear. In this study, we showed that Trem2 in the plasma membrane underwent endocytosis and recycling. Trem2 is internalized in a clat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/tra.12451

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Chinese Academy of Sciences More from this funder
Publisher:
John Wiley & Sons Publisher's website
Journal:
Traffic Journal website
Volume:
17
Issue:
12
Pages:
1286-1296
Publication date:
2016-12-05
DOI:
EISSN:
1600-0854
ISSN:
1398-9219
Pubs id:
pubs:677387
URN:
uri:6f26ebca-c3e8-4f08-8de3-f422974a8320
UUID:
uuid:6f26ebca-c3e8-4f08-8de3-f422974a8320
Local pid:
pubs:677387
Paper number:
12

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