Journal article
Vps35-dependent recycling of Trem2 regulates microglial function
- Abstract:
-
Triggering receptor expressed on myeloid cells 2 (Trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia. However, the intracellular trafficking of Trem2 remains unclear. In this study, we showed that Trem2 in the plasma membrane underwent endocytosis and recycling. Trem2 is internalized in a clat...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Publisher copy:
- 10.1111/tra.12451
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ National Basic Research Program
of China
More from this funder
Grant:
973-
2012CB910701
2013DFA31990
Chinese Academy of Sciences
More from this funder
Bibliographic Details
- Publisher:
- John Wiley & Sons Publisher's website
- Journal:
- Traffic Journal website
- Volume:
- 17
- Issue:
- 12
- Pages:
- 1286-1296
- Publication date:
- 2016-12-01
- Acceptance date:
- 2016-09-21
- DOI:
- EISSN:
-
1600-0854
- ISSN:
-
1398-9219
- Source identifiers:
-
677387
Item Description
- Keywords:
- Pubs id:
-
pubs:677387
- UUID:
-
uuid:6f26ebca-c3e8-4f08-8de3-f422974a8320
- Local pid:
- pubs:677387
- Deposit date:
- 2017-02-08
Terms of use
- Copyright holder:
- John Wiley & Sons
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
If you are the owner of this record, you can report an update to it here: Report update to this record