Journal article
Vps35-dependent recycling of Trem2 regulates microglial function
- Abstract:
-
Triggering receptor expressed on myeloid cells 2 (Trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. Trem2 might be involved in the development of Alzheimer's disease (AD) through regulating the inflammatory responses and phagocytosis of microglia. However, the intracellular trafficking of Trem2 remains unclear. In this study, we showed that Trem2 in the plasma membrane underwent endocytosis and recycling. Trem2 is internalized in a clat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ National Basic Research Program
of China
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Grant:
973-
2012CB910701
2013DFA31990
Chinese Academy of Sciences
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Bibliographic Details
- Publisher:
- John Wiley & Sons Publisher's website
- Journal:
- Traffic Journal website
- Volume:
- 17
- Issue:
- 12
- Pages:
- 1286-1296
- Publication date:
- 2016-12-01
- Acceptance date:
- 2016-09-21
- DOI:
- EISSN:
-
1600-0854
- ISSN:
-
1398-9219
- Source identifiers:
-
677387
Item Description
- Keywords:
- Pubs id:
-
pubs:677387
- UUID:
-
uuid:6f26ebca-c3e8-4f08-8de3-f422974a8320
- Local pid:
- pubs:677387
- Deposit date:
- 2017-02-08
Terms of use
- Copyright holder:
- John Wiley & Sons
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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