Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?
BACKGROUND: There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B and C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 and HLA-Cw*0702 had been suggested by our previous, small study. METHODS: We studied the HLA-B and C alleles in 196 cases of 'definite' or 'probable' AD and 199 elderly controls of the OPTIMA cohort, the largest full study of these alleles in AD to date. RESULTS: We repl...Expand abstract
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