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Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?

Abstract:

BACKGROUND: There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B and C genes have, however, been relatively understudied. A geographically specific association with HLA-B7 and HLA-Cw*0702 had been suggested by our previous, small study. METHODS: We studied the HLA-B and C alleles in 196 cases of 'definite' or 'probable' AD and 199 elderly controls of the OPTIMA cohort, the largest full study of these alleles in AD to date. RESULTS: We repl...

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Publication status:
Published

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Publisher copy:
10.1186/1742-2094-3-33

Authors


Lehmann, DJ More by this author
Barnardo, MC More by this author
Quiroga, I More by this author
Sutherland, A More by this author
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Journal:
Journal of neuroinflammation
Volume:
3
Pages:
33
Publication date:
2006
DOI:
EISSN:
1742-2094
ISSN:
1742-2094
URN:
uuid:6f25af63-0851-4c88-b9b4-ad5c2ecd5aba
Source identifiers:
140541
Local pid:
pubs:140541
Language:
English

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