- Abstract:
-
BACKGROUND: Despite early promise in phase II, the performance of the NK1 receptor antagonist aprepitant in subsequent clinical trials has been disappointing. Healthy volunteer models of emotional processing offer a potential means by which novel drugs can be screened prior to clinical trials. Here, we consider the effect of 7 days of treatment with aprepitant in such a model. METHOD: Healthy volunteers (n = 32) were randomised to receive 7-day treatment with aprepitant (125 mg) or placebo. O...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00213-010-2133-z
-
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- Journal:
- Psychopharmacology
- Volume:
- 215
- Issue:
- 2
- Pages:
- 239-246
- Publication date:
- 2011-05-05
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- URN:
-
uuid:6f246924-fc35-4b71-948a-fa92122fc61a
- Source identifiers:
-
139508
- Local pid:
- pubs:139508
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Short-term NK1 receptor antagonism and emotional processing in healthy volunteers.
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