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Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries.

Abstract:

Angiotensin II has a key role in the control of resistance artery tone and local blood flow. Angiotensin II possesses 2 main receptors. Although angiotensin II type 1 receptor is well known and is involved in the vasoconstrictor and growth properties of angiotensin II, the role of the angiotensin II type 2 receptor (AT2R) remains much less understood. Although AT2R stimulation induces vasodilatation in normotensive rats, it induces vasoconstriction in pathological conditions involving oxidati...

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Publication status:
Published

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Journal:
Hypertension
Volume:
55
Issue:
2
Pages:
339-344
Publication date:
2010-02-01
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Source identifiers:
164556

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