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The CD20 (Bp35) antigen is involved in activation of B cells from the G0 to the G1 phase of the cell cycle.

Abstract:

Two monoclonal antibodies, 1F5 and B1, directed against the CD20 (Bp35) antigen were found to have both stimulatory and inhibitory effects on B cells. 1F5, but not B1, induces small resting tonsillar B cells and prolymphocytic leukemia cells to enlarge, to rapidly increase their RNA synthesis, and to become responsive to growth factors present in mixed lymphocyte reaction supernatants. In addition, 1F5 induces a moderate increase in thymidine uptake, which is accompanied by enhanced viability...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
135
Issue:
6
Pages:
3795-3801
Publication date:
1985-12-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:6f0ac815-80d3-4483-8c0d-3166bfb0ac61
Source identifiers:
35149
Local pid:
pubs:35149

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