Accuracy of haplotype reconstruction from haplotype-tagging single-nucleotide polymorphisms.

Journal article

Many investigators are now using haplotype-tagging single-nucleotide polymorphism (htSNPs) as a way of screening regions of the genome for association with disease. A common approach is to genotype htSNPs in a study population and to use this information to draw inferences about each individual's haplotypic makeup, including SNPs that were not directly genotyped. To test the validity of this approach, we simulated the exercise of typing htSNPs in a large sample of individuals and compared the...

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Authors: Forton, J; Kwiatkowski, D; Rockett, K; Luoni, G; Kimber, M

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 76
• Issue: 3
• Pages: 438-448
• Publication date: 2005-03-01
• DOI: 10.1086/428439
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: Models, Genetic; Biometry; Polymorphism, Single Nucleotide; Female; Linkage Disequilibrium; Genetic Markers; Haplotypes; Genotype; Genomics; Male; Humans