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Journal article

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia

Abstract:

Altered metabolism is a hallmark of cancer. However, the role of genomic changes in metabolic genes driving the tumour metabolic shift remains to be elucidated. Here, we have investigated the genomic and transcriptomic changes underlying this shift across ten different cancer types.A systematic pan-cancer analysis of 6538 tumour/normal samples covering ten major cancer types identified a core metabolic signature of 44 genes that exhibit high frequency somatic copy number gains/amplifications ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13059-016-0999-8

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Cancer Research UK More from this funder
European Union More from this funder
NIHR Oxford Biomedical Research Centre More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Genome biology Journal website
Volume:
17
Issue:
1
Pages:
140
Publication date:
2016-01-01
Acceptance date:
2016-06-06
DOI:
EISSN:
1474-760X
ISSN:
1474-7596
Source identifiers:
632675
Language:
English
Keywords:
Pubs id:
pubs:632675
UUID:
uuid:6f0048b3-3c6f-44e8-85d0-9789e72a25a5
Local pid:
pubs:632675
Deposit date:
2016-07-12

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