- Abstract:
-
Previous studies have demonstrated that G-protein agonists induce quiescence (Q effect) or retraction (R effect) in isolated osteoclasts. We now report the functional effects of such agonists on osteoclastic bone resorption and enzyme release. Exposure of osteoclasts to tetrafluoro-aluminate anions (AlF4-), a universal G protein stimulator, resulted in a marked concentration-dependent inhibition of bone resorption. This was associated with a dramatic increase in the secretion of the osteoclas...
Expand abstract - Publisher copy:
- 10.1006/bbrc.1993.1075
-
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- Journal:
- Biochemical and biophysical research communications
- Volume:
- 190
- Issue:
- 2
- Pages:
- 496-501
- Publication date:
- 1993-01-05
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:6ef7395b-f42a-4081-bc56-a640a353d2f6
- Source identifiers:
-
475724
- Local pid:
- pubs:475724
- Copyright date:
- 1993
Journal article
Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion.
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