Journal article icon

Journal article

Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion.

Abstract:

Previous studies have demonstrated that G-protein agonists induce quiescence (Q effect) or retraction (R effect) in isolated osteoclasts. We now report the functional effects of such agonists on osteoclastic bone resorption and enzyme release. Exposure of osteoclasts to tetrafluoro-aluminate anions (AlF4-), a universal G protein stimulator, resulted in a marked concentration-dependent inhibition of bone resorption. This was associated with a dramatic increase in the secretion of the osteoclas...

Expand abstract

Actions


Access Document


Publisher copy:
10.1006/bbrc.1993.1075

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Expand authors...
Journal:
Biochemical and biophysical research communications
Volume:
190
Issue:
2
Pages:
496-501
Publication date:
1993-01-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:6ef7395b-f42a-4081-bc56-a640a353d2f6
Source identifiers:
475724
Local pid:
pubs:475724

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP