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Stimulation of a Gs-like G protein in the osteoclast inhibits bone resorption but enhances tartrate-resistant acid phosphatase secretion.

Abstract:

Previous studies have demonstrated that G-protein agonists induce quiescence (Q effect) or retraction (R effect) in isolated osteoclasts. We now report the functional effects of such agonists on osteoclastic bone resorption and enzyme release. Exposure of osteoclasts to tetrafluoro-aluminate anions (AlF4-), a universal G protein stimulator, resulted in a marked concentration-dependent inhibition of bone resorption. This was associated with a dramatic increase in the secretion of the osteoclas...

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Publisher copy:
10.1006/bbrc.1993.1075

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Biochemical and biophysical research communications
Volume:
190
Issue:
2
Pages:
496-501
Publication date:
1993-01-01
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Source identifiers:
475724
Language:
English
Keywords:
Pubs id:
pubs:475724
UUID:
uuid:6ef7395b-f42a-4081-bc56-a640a353d2f6
Local pid:
pubs:475724
Deposit date:
2014-07-14

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