Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation.

Journal article

Theiler's murine encephalomyelitis virus (TMEV) is a picornavirus which induces a chronic demyelinating disease of the central nervous system (CNS) in certain susceptible mouse strains. Demyelination has been shown to result from immunopathological responses mediated by CD4+, major histocompatibility complex (MHC) class II-restricted T cells. As little or no class II is expressed in the normal mouse CNS, the ability of astrocytes to express these proteins and present antigen to T cells from T...

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Authors: Borrow, P; Nash, A

• Publication status: Published
• Journal: Immunology
• Volume: 76
• Issue: 1
• Pages: 133-139
• Publication date: 1992-05-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Mice, Inbred BALB C; Antigens, Viral; Mice, Inbred CBA; Maus Elberfeld virus; Interferon-gamma, Recombinant; Antigen-Presenting Cells; Cells, Cultured; Mice, Inbred Strains; Astrocytes; Histocompatibility Antigens Class II; Mice; Disease Susceptibility; Enterovirus Infections; Animals; T-Lymphocytes