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Journal article

Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation.

Abstract:

Theiler's murine encephalomyelitis virus (TMEV) is a picornavirus which induces a chronic demyelinating disease of the central nervous system (CNS) in certain susceptible mouse strains. Demyelination has been shown to result from immunopathological responses mediated by CD4+, major histocompatibility complex (MHC) class II-restricted T cells. As little or no class II is expressed in the normal mouse CNS, the ability of astrocytes to express these proteins and present antigen to T cells from T...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Immunology More from this journal
Volume:
76
Issue:
1
Pages:
133-139
Publication date:
1992-05-01
EISSN:
1365-2567
ISSN:
0019-2805
Language:
English
Keywords:
Pubs id:
pubs:33307
UUID:
uuid:6ef5c82f-5c28-4ba7-b553-46589ae3aab3
Local pid:
pubs:33307
Source identifiers:
33307
Deposit date:
2012-12-19

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