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Declining malaria transmission differentially impacts the maintenance of humoral immunity to Plasmodium falciparum in children

Abstract:

Background

We investigated the poorly understood impact of declining malaria transmission on maintenance of antibodies to Plasmodium falciparum merozoite antigens and infected erythrocytes (IEs), including functional immunity.

Methods

In a 3-year longitudinal cohort of 300 Kenyan children, antibodies to different AMA1 and MSP2 alleles of merozoites, IE surface antigens, and antibody functional activities were quantified.

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jix370

Authors


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Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
216
Issue:
7
Pages:
887-898
Place of publication:
United States
Publication date:
2017-08-02
Acceptance date:
2017-07-31
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
28973483
Language:
English
Keywords:
Pubs id:
735435
Local pid:
pubs:735435
Deposit date:
2020-03-16

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