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Journal article

The role of catechol-O-methyltransferase in reward processing and addiction.

Abstract:

Catechol-O-methyltransferase (COMT) catabolises dopamine and is important for regulating dopamine levels in the prefrontal cortex. Consistent with its regulation of prefrontal cortex dopamine, COMT modulates working memory and executive function; however, its significance for other cognitive domains, and in other brain regions, remains relatively unexplored. One such example is reward processing, for which dopamine is a critical mediator, and in which the striatum and corticostriatal circuitr...

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Publication status:
Published

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Publisher copy:
10.2174/187152712800672409

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
CNS and neurological disorders drug targets
Volume:
11
Issue:
3
Pages:
306-323
Publication date:
2012-05-05
DOI:
EISSN:
1996-3181
ISSN:
1871-5273
URN:
uuid:6ee790ae-d7d8-4468-bd65-57f18a0247d9
Source identifiers:
322685
Local pid:
pubs:322685

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