Primary biliary cirrhosis: contribution of HLA class II allele DR8.

Journal article

Primary biliary cirrhosis is a chronic cholestatic disease of unknown aetiology which predominantly affects middle-aged women. It is thought to be autoimmune in nature, but unlike many autoimmune diseases no clear HLA association has been described. Several studies have suggested conflicting associations with HLA class II, although a DR8 association is most frequently described. To test the hypothesis that primary biliary cirrhosis is associated with a certain HLA class II locus we genotyped ...

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Authors: Gregory, W; Mehal, W; Dunn, A; Cavanagh, G; Chapman, R

• Publication status: Published
• Journal: Quarterly journal of medicine
• Volume: 86
• Issue: 6
• Pages: 393-399
• Publication date: 1993-06-01
• ISSN: 0033-5622
• Language: English
• Keywords: Polymorphism, Restriction Fragment Length; Alleles; Aged; Humans; Polymerase Chain Reaction; Liver Cirrhosis, Biliary; Aged, 80 and over; Adult; Female; Male; HLA-DR Antigens; Middle Aged