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PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

Abstract:

Pancreatic ductal adenocarcinoma (PDAC) is considered a non-immunogenic tumor and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of KPC and Pan02 murine PDAC cells with RT and gemcitabine upregulated PD-L1 expression in a JAK/Stat1-dependent manner. In vitro, PD-L1 inhibition did not alter radio- and chemosensitivity. In vivo, addition of anti-PD-L1 to high (12 G...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/emmm.201606674

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Department:
Oxford, MSD, Pathology Dunn School
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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
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Cancer Research UK More from this funder
Marie Curie Innovative Training Network More from this funder
Kidani Memorial Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
EMBO Molecular Medicine Journal website
Volume:
9
Issue:
1
Pages:
1 - 132
Publication date:
2016-12-07
Acceptance date:
2016-10-28
DOI:
ISSN:
1757-4684
Pubs id:
pubs:657527
URN:
uri:6ed98f65-9d77-41d4-8684-08eb13de1035
UUID:
uuid:6ed98f65-9d77-41d4-8684-08eb13de1035
Local pid:
pubs:657527

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