Journal article
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites
- Abstract:
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Protein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these sites have not been elucidated. Here, we report of three novel and diverse protein kinase structures that reveal an exchanged activation segment conformation. This dimeric arrangement results in an active kinase conformation in trans, with activation ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 545.1KB)
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- Publisher copy:
- 10.1038/emboj.2008.8
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Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 27
- Issue:
- 4
- Pages:
- 704-714
- Publication date:
- 2008-02-01
- DOI:
- EISSN:
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1460 - 2075
- ISSN:
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0261 - 4189
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:6ec6c1ee-2eea-4c4c-a10d-9fd76f7c5877
- Local pid:
- ora:2400
- Deposit date:
- 2008-10-20
Related Items
Terms of use
- Copyright holder:
- A C W Pike et al
- Copyright date:
- 2008
- Notes:
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Citation: 'Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites', The EMBO Journal, 27(4), 704-714. [Available at http://www.nature.com/emboj]. This is an open-access article distributed under the terms of the Creative Commons Attribution License [http://creativecommons.org/licenses/by-nc-nd/2.5/], which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.
The Structural Genomics Consortium is a registered charity (number 1097737) that receives funds from the Canadian Institutes for Health
Research, the Canadian Foundation for Innovation, Genome Canada through the Ontario Genomics Institute, GlaxoSmithKline, Karolinska Institute, the Knut and Alice Wallenberg Foundation, the Ontario Innovation Trust, the Ontario Ministry for Research and Innovation, Merck & Co Inc., the Novartis Research Foundation, the Swedish Agency for Innovation Systems, the Swedish Foundation for Strategic Research and the Wellcome Trust.
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