Journal article icon

Journal article

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

Abstract:

Protein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these sites have not been elucidated. Here, we report of three novel and diverse protein kinase structures that reveal an exchanged activation segment conformation. This dimeric arrangement results in an active kinase conformation in trans, with activation ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/emboj.2008.8

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
"Institute of Cancer Research, Chelsea, London, UK"
Department:
Cancer Research UK,DNA Repair Enzymes Group,Section of Structural Biology
Role:
Author
Expand authors...

Contributors

More from this funder
Funding agency for:
Parker, S
Grant:
GM079498
More from this funder
Funding agency for:
Oliver, A
More from this funder
Funding agency for:
Pearl, L
More from this funder
Funding agency for:
Turk, B
Grant:
GM079498
Publisher:
Nature Publishing Group Publisher's website
Journal:
EMBO Journal Journal website
Volume:
27
Issue:
4
Pages:
704-714
Publication date:
2008-02-01
DOI:
EISSN:
1460 - 2075
ISSN:
0261 - 4189
Language:
English
Keywords:
Subjects:
UUID:
uuid:6ec6c1ee-2eea-4c4c-a10d-9fd76f7c5877
Local pid:
ora:2400
Deposit date:
2008-10-20

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP