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Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose.

Abstract:

The cytosolic Ca2+ activity of insulin-releasing clonal cells (RINm5F) was studied with the intracellular fluorescent indicator quin-2. When the extracellular Ca2+ concentration was 1 mM, the basal cytosolic Ca2+ activity was 101 +/- 5 nM. Depolarization with 25 mM K+ increased this Ca2+ activity to at least 318 nM, an effect completely reversed by the voltage-dependent channel blocker D-600. In the presence of K+ alone these channels appeared to have a half-life of 6.7 +/- 0.8 min. In contra...

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Publication status:
Published

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Publisher copy:
10.1007/bf01140663

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Publisher:
Kluwer Academic Publishers
Journal:
Bioscience reports
Volume:
3
Issue:
10
Pages:
939-946
Publication date:
1983-10-05
DOI:
EISSN:
1573-4935
ISSN:
0144-8463
URN:
uuid:6ec2a1f8-b2c8-4808-a071-28a21f028827
Source identifiers:
4032
Local pid:
pubs:4032

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