- Abstract:
-
The cytosolic Ca2+ activity of insulin-releasing clonal cells (RINm5F) was studied with the intracellular fluorescent indicator quin-2. When the extracellular Ca2+ concentration was 1 mM, the basal cytosolic Ca2+ activity was 101 +/- 5 nM. Depolarization with 25 mM K+ increased this Ca2+ activity to at least 318 nM, an effect completely reversed by the voltage-dependent channel blocker D-600. In the presence of K+ alone these channels appeared to have a half-life of 6.7 +/- 0.8 min. In contra...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/bf01140663
-
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- Publisher:
- Kluwer Academic Publishers
- Journal:
- Bioscience reports
- Volume:
- 3
- Issue:
- 10
- Pages:
- 939-946
- Publication date:
- 1983-10-05
- DOI:
- EISSN:
-
1573-4935
- ISSN:
-
0144-8463
- URN:
-
uuid:6ec2a1f8-b2c8-4808-a071-28a21f028827
- Source identifiers:
-
4032
- Local pid:
- pubs:4032
- Language:
- English
- Keywords:
- Copyright date:
- 1983
Journal article
Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose.
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