Diseases associated with the extracellular calcium-sensing receptor.

Journal article

Abstract:: The human calcium-sensing receptor (CaSR) is a 1078 amino acid cell surface protein, which is predominantly expressed in the parathyroids and kidney, and is a member of the family of G protein-coupled receptors. The CaSR allows regulation of parathyroid hormone (PTH) secretion and renal tubular calcium reabsorption in response to alterations in extracellular calcium concentrations. The human CaSR gene is located on chromosome 3q21.1 and loss-of-function CaSR mutations have been reported in th...
Expand abstract
Collapse abstract

Institution:

University of Oxford

Division:

MSD

Department:

RDM

Sub department:

OCDEM

Role:

Author

Language:: English
Keywords:: Hypoparathyroidism

Humans

Receptors, Calcium-Sensing

Calcium Metabolism Disorders

Autoimmune Diseases

Models, Biological

Mutation

Hypercalcemia

Hypocalcemia

Hyperparathyroidism
Pubs id:: pubs:6739
UUID:: uuid:6eb9dea2-b647-41ce-aef4-50af7ce07b8c
Local pid:: pubs:6739
Source identifiers:: 6739
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

If you are the owner of this record, you can report an update to it here: Report update to this record