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Identification of 34 novel proinflammatory proteins in a genome-wide macrophage functional screen.

Abstract:

Signal transduction pathways activated by Toll-like Receptors and the IL-1 family of cytokines are fundamental to mounting an innate immune response and thus to clearing pathogens and promoting wound healing. Whilst mechanistic understanding of the regulation of innate signalling pathways has advanced considerably in recent years, there are still a number of critical controllers to be discovered. In order to characterise novel regulators of macrophage inflammation, we have carried out an exte...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0042388

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Foundation for the National Institutes of Health More from this funder
Grand Challenges in Global Health Initiative of the Gates Foundation More from this funder
Sheffield National Institute for Health Research Cardiovascular Biomedical Research Unit More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
7
Pages:
Article: e42388
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:6eb9af39-1842-4744-b684-65a63b50079f
Source identifiers:
344301
Local pid:
pubs:344301

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