Journal article icon

Journal article

Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.

Abstract:

A consistent feature of the Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) is the constitutive activation of NF-kappaB transcription factors. In Epstein-Barr virus (EBV)-associated cases of cHL, expression of viral antigens most probably leads to NF-kappaB activation but for non-EBV-associated cases, the mechanism is not clear. Previous small studies have demonstrated deleterious mutations of NFKBIA, the gene encoding IkappaB alpha, in HRS cells. In the present stu...

Expand abstract

Actions


Access Document


Publisher copy:
10.1002/ijc.24502

Authors


Journal:
International journal of cancer. Journal international du cancer More from this journal
Volume:
125
Issue:
6
Pages:
1334-1342
Publication date:
2009-09-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP