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Journal article

The population genetics of using homing endonuclease genes in vector and pest management.

Abstract:

Homing endonuclease genes (HEGs) encode proteins that in the heterozygous state cause double-strand breaks in the homologous chromosome at the precise position opposite the HEG. If the double-strand break is repaired using the homologous chromosome, the HEG becomes homozygous, and this represents a powerful genetic drive mechanism that might be used as a tool in managing vector or pest populations. HEGs may be used to decrease population fitness to drive down population densities (possibly ca...

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Publication status:
Published

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Publisher copy:
10.1534/genetics.108.089037

Authors


Journal:
Genetics
Volume:
179
Issue:
4
Pages:
2013-2026
Publication date:
2008-08-05
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
URN:
uuid:6ea73373-dd8e-4bfc-b07f-b6a35d2054a4
Source identifiers:
210589
Local pid:
pubs:210589

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