- Abstract:
-
A widely accepted hypothesis is that long-term potentiation (LTP) is a synaptic mechanism of memory. NMDA receptors are critically involved in induction but not maintenance of LTP; therefore, their blockade should impair memory acquisition but not retrieval. In Experiment 1, we investigated the effect of a systemic NMDA receptor antagonist, CGP-40116 [D-isomer of CGP-37849: (E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (6 mg/kg, i.m.) 60 min before the testing session] on memory acquisiti...
Expand abstract - Publication status:
- Published
- Journal:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Volume:
- 16
- Issue:
- 12
- Pages:
- 4041-4045
- Publication date:
- 1996-06-05
- EISSN:
-
1529-2401
- ISSN:
-
0270-6474
- URN:
-
uuid:6ea5aa27-aaf0-4d0a-9add-be9047533450
- Source identifiers:
-
17317
- Local pid:
- pubs:17317
- Copyright date:
- 1996
Journal article
Systemic NMDA receptor antagonist CGP-40116 does not impair memory acquisition but protects against NMDA neurotoxicity in rhesus monkeys.
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