Journal article icon

Journal article

Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy

Abstract:

The tumour suppressor p53 is a master sensor of stress and it controls the expression of hundreds to thousands of genes with diverse biological functions including cell cycle arrest, apoptosis, and senescence. Consequently p53 is the most mutated gene found in human cancer and p53 mutation rate varies from 5% to 95%. Importantly p53 activity is often inactivated in tumours expressing structurally wild type p53. Thus one of the major challenges in cancer research is to restore the tumour suppr...

Expand abstract

Actions


Access Document


Publisher:
Elsevier
Journal:
FEBS Letters More from this journal
Volume:
588
Issue:
16
Pages:
2616-2621
Publication date:
2014-08-19
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:480594
UUID:
uuid:6ea3dd57-9318-4ac2-a51f-c9f2cc0a93bd
Local pid:
pubs:480594
Source identifiers:
480594
Deposit date:
2014-08-29

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP