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Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats.

Abstract:

Hypertension is associated with the early onset of cardiac sympathetic hyperresponsiveness and enhanced intracellular Ca(2+) concentration [Ca(2+)](i) in sympathetic neurons from both prehypertensive and hypertensive, spontaneously hypertensive rats (SHRs). Oxidative stress is a hallmark of hypertension, therefore, we tested the hypothesis that the inhibitory action of the nitric oxide-cGMP pathway on [Ca(2+)](i) transients is impaired in cardiac sympathetic neurons from the SHR. Stellate gan...

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Publication status:
Published

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Journal:
Hypertension
Volume:
61
Issue:
1
Pages:
202-207
Publication date:
2013-01-05
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
URN:
uuid:6e96f5d2-3c39-46d8-8feb-935d8a317d88
Source identifiers:
363832
Local pid:
pubs:363832

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