Journal article
Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats.
- Abstract:
-
Hypertension is associated with the early onset of cardiac sympathetic hyperresponsiveness and enhanced intracellular Ca(2+) concentration [Ca(2+)](i) in sympathetic neurons from both prehypertensive and hypertensive, spontaneously hypertensive rats (SHRs). Oxidative stress is a hallmark of hypertension, therefore, we tested the hypothesis that the inhibitory action of the nitric oxide-cGMP pathway on [Ca(2+)](i) transients is impaired in cardiac sympathetic neurons from the SHR. Stellate gan...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/hypertensionaha.111.00105
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Authors
Bibliographic Details
- Journal:
- Hypertension
- Volume:
- 61
- Issue:
- 1
- Pages:
- 202-207
- Publication date:
- 2013-01-05
- DOI:
- EISSN:
-
1524-4563
- ISSN:
-
0194-911X
- URN:
-
uuid:6e96f5d2-3c39-46d8-8feb-935d8a317d88
- Source identifiers:
-
363832
- Local pid:
- pubs:363832
Item Description
Terms of use
- Copyright date:
- 2013
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