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Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation

Abstract:

Staphylococcus aureus is a notorious human bacterial pathogen with considerable capacity to develop antibiotic resistance. We have observed that human infections caused by highly drug-resistant S. aureus are more prolonged, complicated, and difficult to eradicate. Here we describe a metabolic adaptation strategy used by clinical S. aureus strains that leads to resistance to the last-line antibiotic, daptomycin, and simultaneously affects host innate immunity. This response was characterized b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1073/pnas.1812066116

Authors


Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
9
Pages:
3722-3727
Publication date:
2019-02-11
Acceptance date:
2018-11-28
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
30808758
Language:
English
Keywords:
Pubs id:
pubs:980969
UUID:
uuid:6e969476-55fd-4236-8801-fad028550690
Local pid:
pubs:980969
Source identifiers:
980969
Deposit date:
2019-03-25

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