- Abstract:
-
BACKGROUND AND PURPOSE: Intracellular pH (pH(i)) in heart is regulated by sarcolemmal H(+)-equivalent transporters such as Na(+)-H(+) exchange (NHE) and Na(+)-HCO(3) (-) cotransport (NBC). Inhibition of NBC influences pH(i) and can be cardioprotective in animal models of post-ischaemic reperfusion. Apart from a rabbit polyclonal NBC-antibody, a selective NBC inhibitor compound has not been studied. Compound S0859 (C(29)H(24)ClN(3)O(3)S) is a putative NBC inhibitor. Here, we provide the drug's...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.bjp.0707667
-
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- Journal:
- British journal of pharmacology
- Volume:
- 153
- Issue:
- 5
- Pages:
- 972-982
- Publication date:
- 2008-03-05
- DOI:
- EISSN:
-
1476-5381
- ISSN:
-
0007-1188
- URN:
-
uuid:6e939b16-72b4-43f8-a5dd-9b86cbc0c815
- Source identifiers:
-
106506
- Local pid:
- pubs:106506
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart.
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