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S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart.

Abstract:

BACKGROUND AND PURPOSE: Intracellular pH (pH(i)) in heart is regulated by sarcolemmal H(+)-equivalent transporters such as Na(+)-H(+) exchange (NHE) and Na(+)-HCO(3) (-) cotransport (NBC). Inhibition of NBC influences pH(i) and can be cardioprotective in animal models of post-ischaemic reperfusion. Apart from a rabbit polyclonal NBC-antibody, a selective NBC inhibitor compound has not been studied. Compound S0859 (C(29)H(24)ClN(3)O(3)S) is a putative NBC inhibitor. Here, we provide the drug's...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0707667

Authors


Villafuerte, FC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Cobden, PM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
British journal of pharmacology
Volume:
153
Issue:
5
Pages:
972-982
Publication date:
2008-03-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:6e939b16-72b4-43f8-a5dd-9b86cbc0c815
Source identifiers:
106506
Local pid:
pubs:106506

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