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Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.

Abstract:

Clavaminate synthase (CAS), a remarkable Fe(II)/2-oxoglutarate oxygenase, catalyzes three separate oxidative reactions in the biosynthesis of clavulanic acid, a clinically used inhibitor of serine beta-lactamases. The first CAS-catalyzed step (hydroxylation) is separated from the latter two (oxidative cyclization/desaturation) by the action of an amidinohydrolase. Here, we describe crystal structures of CAS in complex with Fe(II), 2-oxoglutarate (2OG) and substrates (N-alpha-acetyl-L-arginine...

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Publication status:
Published

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Publisher copy:
10.1038/72398

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Journal:
Nature structural biology
Volume:
7
Issue:
2
Pages:
127-133
Publication date:
2000-02-05
DOI:
ISSN:
1072-8368
URN:
uuid:6e91d123-beac-45ee-9317-2f68c28c88ed
Source identifiers:
31613
Local pid:
pubs:31613

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