- Abstract:
-
Clavaminate synthase (CAS), a remarkable Fe(II)/2-oxoglutarate oxygenase, catalyzes three separate oxidative reactions in the biosynthesis of clavulanic acid, a clinically used inhibitor of serine beta-lactamases. The first CAS-catalyzed step (hydroxylation) is separated from the latter two (oxidative cyclization/desaturation) by the action of an amidinohydrolase. Here, we describe crystal structures of CAS in complex with Fe(II), 2-oxoglutarate (2OG) and substrates (N-alpha-acetyl-L-arginine...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/72398
-
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- Journal:
- Nature structural biology
- Volume:
- 7
- Issue:
- 2
- Pages:
- 127-133
- Publication date:
- 2000-02-05
- DOI:
- ISSN:
-
1072-8368
- URN:
-
uuid:6e91d123-beac-45ee-9317-2f68c28c88ed
- Source identifiers:
-
31613
- Local pid:
- pubs:31613
- Copyright date:
- 2000
Journal article
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
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