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Induction of functional specific antibodies, IgG-secreting plasmablasts and memory B cells following BCG vaccination

Abstract:

Tuberculosis (TB) is a major global health problem and the only currently-licensed vaccine, BCG, is inadequate. Many TB vaccine candidates are designed to be given as a boost to BCG; an understanding of the BCG-induced immune response is therefore critical, and the opportunity to relate this to circumstances where BCG does confer protection may direct the design of more efficacious vaccines. While the T cell response to BCG vaccination has been well-characterized, there is a paucity of litera...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2021.798207

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
12
Article number:
798207
Publication date:
2021-01-01
Acceptance date:
2021-12-13
DOI:
EISSN:
1664-3224
Pmid:
35069580
Language:
English
Keywords:
Pubs id:
1236145
Local pid:
pubs:1236145
Deposit date:
2022-02-08

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