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Journal article

Metastability of native proteins and the phenomenon of amyloid formation.

Abstract:
An experimental determination of the thermodynamic stabilities of a series of amyloid fibrils reveals that this structural form is likely to be the most stable one that protein molecules can adopt even under physiological conditions. This result challenges the conventional assumption that functional forms of proteins correspond to the global minima in their free energy surfaces and suggests that living systems are conformationally as well as chemically metastable.
Publication status:
Published

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Publisher copy:
10.1021/ja2017703

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Journal:
Journal of the American Chemical Society More from this journal
Volume:
133
Issue:
36
Pages:
14160-14163
Publication date:
2011-09-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Language:
English
Keywords:
Pubs id:
pubs:385505
UUID:
uuid:6e8d92f2-3142-44e2-a712-ec542193a55a
Local pid:
pubs:385505
Source identifiers:
385505
Deposit date:
2013-11-16

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