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Global Genetic Architecture of an Erythroid Quantitative Trait Locus, HMIP-2

Abstract:

HMIP-2 is a human quantitative trait locus affecting peripheral numbers, size and hemoglobin composition of red blood cells, with a marked effect on the persistence of the fetal form of hemoglobin, HbF, in adults. The locus consists of multiple common variants in an enhancer region for MYB (chr 6q23.3), which encodes the hematopoietic transcription factor cMYB. Studying a European population cohort and four African-descended groups of patients with sickle cell anemia, we found that all share ...

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Publisher copy:
10.1111/ahg.12077

Authors


Publisher:
Blackwell Publishing Ltd
Journal:
Annals of Human Genetics More from this journal
Volume:
78
Issue:
6
Pages:
434-451
Publication date:
2014-11-01
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
Language:
English
Keywords:
Pubs id:
pubs:489176
UUID:
uuid:6e8b1eae-ef29-4f35-8fc9-1017996770a7
Local pid:
pubs:489176
Source identifiers:
489176
Deposit date:
2014-11-16

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