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An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

Abstract:

BACKGROUND: Familial cylindromatosis is a rare genetic disorder, giving rise to neoplasms of the skin appendages. We have recently shown that loss of the cylindromatosis tumour suppressor gene leads to activation of NF-kappaB, a transcription factor having antiapoptotic activity. This provides a possible explanation for the deregulated growth of cylindromas. In cell-based assays, salicylate can prevent NF-kappaB activation caused by loss of the cylindromatosis gene, suggesting that salicylic ...

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Authors


Oosterkamp, HM More by this author
Neering, H More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
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Journal:
The British journal of dermatology
Volume:
155
Issue:
1
Pages:
182-185
Publication date:
2006-07-05
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
URN:
uuid:6e869066-82bc-4d4c-9bfc-3f2999b2f741
Source identifiers:
489970
Local pid:
pubs:489970

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