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Cholera toxin binds to LewisX and fucosylated glycoproteins play a functional role in human intestinal cell intoxication

Abstract:

Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors via its B subunit (CTB). We have recently shown that in addition to the previously described binding partner ganglioside GM1, CTB binds to fucosylated proteins. Using flow cytometric analysis of primary human jejunal epithelial cells and granulocytes, we now show that CTB binding correlates with expression of the fucosylated Lewis X (LeX) glycan. This binding is competitively blocked by fucosylated olig...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1093/glycob/cwx086

Authors


Casselbrant, A More by this author
Cvjetkovic, A More by this author
Estelius, J More by this author
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Publisher:
Oxford University Press Publisher's website
Volume:
27
Issue:
12
Pages:
1171–1255
Publication date:
2017-10-27
Acceptance date:
2017-02-07
DOI:
ISSN:
1460-2423 and 0959-6658
Pubs id:
pubs:824715
URN:
uri:6e80ccd9-78ca-4a96-bc3d-6d8dbd4f0ff3
UUID:
uuid:6e80ccd9-78ca-4a96-bc3d-6d8dbd4f0ff3
Local pid:
pubs:824715

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