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Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key.

Abstract:

Cytotoxic T lymphocytes (CTL) are essential for control of primary infections by many pathogens and in particular by non-cytopathic viruses. It has been proposed that long-term maintenance of CTL memory and control of lymphocytic choriomeningitis virus (LCMV) is dependent upon the presence of T helper cells and interaction of antigen-presenting cells and CTL via CD40 and its ligand CD40L. However, we demonstrate here that CD40-CD40L interaction maintains CTL memory by induction of virus-speci...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200324717

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
European journal of immunology More from this journal
Volume:
34
Issue:
2
Pages:
317-326
Publication date:
2004-02-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980

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