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Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract.

Abstract:
The gastrointestinal tract provides a variety of environmental challenges to any bacterium seeking to successfully colonize or cause disease in a host. A major obstacle is the varied oxygen concentrations encountered at different sites in the intestine. Here we review the mechanisms bacterial pathogens utilize to sense oxygen within the gastrointestinal tract, and recent insights into how this acts as a signal to trigger virulence and to modulate host responses.

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cellular microbiology More from this journal
Volume:
13
Issue:
2
Pages:
171-176
Publication date:
2011-02-01
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
Language:
English
Keywords:
Pubs id:
pubs:249466
UUID:
uuid:6e7c3a71-0e8a-4643-9677-89d24eca4fbb
Local pid:
pubs:249466
Source identifiers:
249466
Deposit date:
2012-12-19

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