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Thesis

The molecular determinants of Polycomb-mediated gene repression

Abstract:

Precise spatio-temporal regulation of gene expression is required for development of multicellular organisms. Combinatorial activity of DNA-binding transcription factors has been proposed to drive lineage-specific transcriptional programmes. However, in addition to this, the chromatin template, on which transcription occurs, has emerged as another central player in the control of gene expression. The Polycomb repressive system represents one of the most extensively studied paradigms for ch...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Grant:
Funding agency for:
Fursova, N
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:6e792a56-988c-4021-9d8b-860251914a53

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