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Journal article

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

Abstract:

Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we applied a non-biased hypothesis-generating approach to quantify global protein and metabolite changes in the LV of mice stratified for [Cr] levels: wildtype, moderately elevated, and high [Cr] (65-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00726-016-2236-x

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Name:
Department of Health
Grant:
NationalInstituteforHealthResearch(NIHR)BiomedicalResearchCentrebasedatGuy’s
StThomas’NHSFoundationTrust
King’sCollegeLondon
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Name:
King’s College London British Heart Foundation Centre
Grant:
RE/08/003
More from this funder
Name:
Wellcome Trust
Grant:
090532/Z/09/Z
More from this funder
Name:
British Heart Foundation
Grant:
RG/13/8/30266
Publisher:
Springer Verlag
Journal:
Amino Acids More from this journal
Volume:
48
Issue:
8
Pages:
1969-1981
Publication date:
2016-05-03
Acceptance date:
2016-04-11
DOI:
EISSN:
1438-2199
ISSN:
0939-4451
Language:
English
Keywords:
Pubs id:
pubs:619400
UUID:
uuid:6e74ce6e-c7b8-4f90-a834-5d37b384eeb2
Local pid:
pubs:619400
Source identifiers:
619400
Deposit date:
2016-05-20

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