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Predictors of mood response to acute tryptophan depletion. A reanalysis.

Abstract:

Acute tryptophan depletion (ATD) induces depressive symptoms in 50-60% of selective serotonin reuptake inhibitor (SSRI) treated, recovered depressed patients. However, no reliable predictors of mood response to ATD have been established. In the present study, individual subject data of six ATD studies were pooled ('mega-analysis') in order to investigate the mediating role of clinical, demographic and biochemical characteristics in the mood response to ATD. A procedure was developed to make d...

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Publication status:
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Authors


Van der Does, W More by this author
Benkelfat, C More by this author
Bremner, JD More by this author
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Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
27
Issue:
5
Pages:
852-861
Publication date:
2002-11-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:6e6d389d-0751-4a31-8699-d7de82322f7d
Source identifiers:
185865
Local pid:
pubs:185865

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