Cellular mechanisms of bone resorption in breast carcinoma.

Journal article

The cellular mechanisms that account for the increase in osteoclast numbers and bone resorption in skeletal breast cancer metastasis are unclear. Osteoclasts are marrow-derived cells which form by fusion of mononuclear phagocyte precursors that circulate in the monocyte fraction. In this study we have determined whether circulating osteoclast precursors are increased in number or have an increased sensitivity to humoral factors for osteoclastogenesis in breast cancer patients with skeletal me...

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Authors: Hunt, N; Fujikawa, Y; Sabokbar, A; Itonaga, I; Harris, A

• Publication status: Published
• Journal: British journal of cancer
• Volume: 85
• Issue: 1
• Pages: 78-84
• Publication date: 2001-07-01
• DOI: 10.1054/bjoc.2001.1856
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Calcitriol; Bone Neoplasms; Bone Resorption; Proteins; Culture Media, Conditioned; Osteoclasts; Parathyroid Hormone-Related Protein; Macrophages; Interleukin-6; Cell Differentiation; Humans; Aged, 80 and over; Macrophage Colony-Stimulating Factor; Middle Aged; Coculture Techniques; Breast Neoplasms; Immunohistochemistry; Monocytes; Aged; Female