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Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles.

Abstract:

The protein NuMA localizes to mitotic spindle poles where it contributes to the organization of microtubules. In this study, we demonstrate that NuMA loses its stable association with the spindle poles after anaphase onset. Using extracts from Xenopus laevis eggs, we show that NuMA is dephosphorylated in anaphase and released from dynein and dynactin. In the presence of a nondegradable form of cyclin B (Delta90), NuMA remains phosphorylated and associated with dynein and dynactin, and remains...

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Publisher copy:
10.1038/sj.embor.7400046

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
EMBO reports
Volume:
5
Issue:
1
Pages:
97-103
Publication date:
2004-01-01
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Source identifiers:
273231
Language:
English
Keywords:
Pubs id:
pubs:273231
UUID:
uuid:6e621cdc-cf76-495b-9635-0a60293769c4
Local pid:
pubs:273231
Deposit date:
2013-11-17

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