Journal article
Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles.
- Abstract:
-
The protein NuMA localizes to mitotic spindle poles where it contributes to the organization of microtubules. In this study, we demonstrate that NuMA loses its stable association with the spindle poles after anaphase onset. Using extracts from Xenopus laevis eggs, we show that NuMA is dephosphorylated in anaphase and released from dynein and dynactin. In the presence of a nondegradable form of cyclin B (Delta90), NuMA remains phosphorylated and associated with dynein and dynactin, and remains...
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- Publisher copy:
- 10.1038/sj.embor.7400046
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Authors
Bibliographic Details
- Journal:
- EMBO reports
- Volume:
- 5
- Issue:
- 1
- Pages:
- 97-103
- Publication date:
- 2004-01-01
- DOI:
- EISSN:
-
1469-3178
- ISSN:
-
1469-221X
- Source identifiers:
-
273231
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:273231
- UUID:
-
uuid:6e621cdc-cf76-495b-9635-0a60293769c4
- Local pid:
- pubs:273231
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2004
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