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Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses

Abstract:

Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regressio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/cam4.1445

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ORCID:
0000-0002-4992-2458
O'Mara, TA More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Cheng, THT More by this author
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Publisher:
Wiley Publisher's website
Journal:
Cancer Medicine Journal website
Volume:
7
Issue:
5
Pages:
1978-1987
Publication date:
2018-04-02
Acceptance date:
2018-01-21
DOI:
EISSN:
2045-7634
Pubs id:
pubs:834098
URN:
uri:6e5fe44b-a59f-4b35-85be-b9451e4055a2
UUID:
uuid:6e5fe44b-a59f-4b35-85be-b9451e4055a2
Local pid:
pubs:834098

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