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Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses

Abstract:

Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic data as an alternative approach to investigate shared biological etiology of these two diseases. Genetic correlation analysis of summary level statistics from genomewide association studies (GWAS) using LD Score regressio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cam4.1445

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Role:
Author
ORCID:
0000-0002-4992-2458
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Cancer Medicine Journal website
Volume:
7
Issue:
5
Pages:
1978-1987
Publication date:
2018-04-02
Acceptance date:
2018-01-21
DOI:
EISSN:
2045-7634
Pmid:
29608257
Source identifiers:
834098
Language:
English
Keywords:
Pubs id:
pubs:834098
UUID:
uuid:6e5fe44b-a59f-4b35-85be-b9451e4055a2
Local pid:
pubs:834098
Deposit date:
2018-05-09

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