The glycosylation of the variant surface glycoproteins and procyclic acidic repetitive proteins of Trypanosoma brucei

Journal article

Trypanosoma brucei, in common with the other African trypanosomes, exhibits unusual cell-surface molecular architecture. The bloodstream form of the parasite is coated with a continuous layer of approximately five million variant surface glycoprotein (VSG) dimers that provide the parasite with a macromolecular diffusion barrier to guard against lysis by the alternative complement pathway. The procyclic form of the parasite has a more diffuse cell-surface coat made up of approximately 2.5 mill...

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Authors: Mehlert, A; Zitzmann, N; Richardson, J; Treumann, A; Ferguson, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier Publisher's website
• Journal: Molecular and Biochemical Parasitology Journal website
• Volume: 91
• Issue: 1
• Pages: 145-152
• Publication date: 1998-06-15
• DOI: 10.1016/s0166-6851(97)00187-4
• EISSN: 1872-9428
• ISSN: 0166-6851
• Language: English
• Keywords: variant surface glycoproteins, trypanosoma; carbohydrate conformation; life cycle stages; protozoan proteins; carbohydrate sequence; molecular sequence data; membrane glycoproteins; glycosylphosphatidylinositols; glycosylation; trypanosoma brucei brucei; models, molecular