- Abstract:
-
RATIONALE: Neuropsychiatric behaviours in Alzheimer's disease (AD) patients have been associated with neocortical alterations of presynaptic cholinergic and muscarinic M2 receptor markers. In contrast, it is unclear whether non-M2 muscarinic receptors have a role to play in AD behavioural symptoms. OBJECTIVES: To correlate the alterations of neocortical postsynaptic muscarinic receptors with clinical features of AD. MATERIALS AND METHODS: [(3)H]4-DAMP were used in binding assays with lysates...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00213-008-1124-9
-
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- Journal:
- Psychopharmacology
- Volume:
- 198
- Issue:
- 2
- Pages:
- 251-259
- Publication date:
- 2008-06-05
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- URN:
-
uuid:6e58d068-1522-4601-9e7d-f9f9044e3702
- Source identifiers:
-
180268
- Local pid:
- pubs:180268
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis.
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