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Journal article

Loss of [3H]4-DAMP binding to muscarinic receptors in the orbitofrontal cortex of Alzheimer's disease patients with psychosis.

Abstract:

RATIONALE: Neuropsychiatric behaviours in Alzheimer's disease (AD) patients have been associated with neocortical alterations of presynaptic cholinergic and muscarinic M2 receptor markers. In contrast, it is unclear whether non-M2 muscarinic receptors have a role to play in AD behavioural symptoms. OBJECTIVES: To correlate the alterations of neocortical postsynaptic muscarinic receptors with clinical features of AD. MATERIALS AND METHODS: [(3)H]4-DAMP were used in binding assays with lysates...

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Publication status:
Published

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Publisher copy:
10.1007/s00213-008-1124-9

Authors


Francis, PT More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Psychopharmacology
Volume:
198
Issue:
2
Pages:
251-259
Publication date:
2008-06-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:6e58d068-1522-4601-9e7d-f9f9044e3702
Source identifiers:
180268
Local pid:
pubs:180268

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