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Factors involved in entry of the human immunodeficiency virus type 1 into permissive cells: lack of evidence of a role for CD26.

Abstract:

It has been proposed recently that the cell surface peptidase CD26 acts in concert with CD4, the human immunodeficiency virus (HIV) primary receptor molecule, to mediate HIV entry into permissive cells. We have failed to detect significant levels of CD26 cell surface expression and enzymatic activity in a number of commonly propagated human CD4+ cell lines, although CD26 mRNA was present at very low levels, as detected by reverse transcription PCR. No relationship existed between the expressi...

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Publication status:
Published

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Journal:
Journal of virology More from this journal
Volume:
68
Issue:
10
Pages:
6535-6546
Publication date:
1994-10-01
EISSN:
1098-5514
ISSN:
0022-538X

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