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Bromo-deaza-SAH: A potent and selective DOT1L inhibitor

Abstract:

Chemical inhibition of proteins involved in chromatin-mediated signaling is an emerging strategy to control chromatin compaction with the aim to reprogram expression networks to alter disease states. Protein methyltransferases constitute one of the protein families that participate in epigenetic control of gene expression, and represent a novel therapeutic target class. Recruitment of the protein lysine methyltransferase DOT1L at aberrant loci is a frequent mechanism driving acute lymphoid an...

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Publisher copy:
10.1016/j.bmc.2013.01.049

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Journal:
Bioorganic and Medicinal Chemistry More from this journal
Volume:
21
Issue:
7
Pages:
1787-1794
Publication date:
2013-04-01
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
Language:
English
Keywords:
Pubs id:
pubs:395218
UUID:
uuid:6e538ffa-8265-4019-8a26-8e6f5d74e5dd
Local pid:
pubs:395218
Source identifiers:
395218
Deposit date:
2013-11-17

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