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An immune basis for malaria protection by the sickle cell trait.

Abstract:

BACKGROUND: Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it probably involves innate factors such as the reduced ability of Plasmodium falciparum parasites to grow and multiply in HbAS erythrocytes, recent observations suggest that it might also involve the accelerated acquisition of malaria-specific immu...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Journal:
PLoS medicine
Volume:
2
Issue:
5
Pages:
e128
Publication date:
2005-05-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Source identifiers:
39548
Language:
English
Keywords:
Pubs id:
pubs:39548
UUID:
uuid:6e5295ec-343f-4b61-b9c8-0184d4430027
Local pid:
pubs:39548
Deposit date:
2012-12-19

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