Notch3 signalling promotes tumour growth in colorectal cancer.

Journal article

Increased Notch1 activity has been observed in intestinal tumours, partially accomplished by β-catenin-mediated up-regulation of the Notch ligand Jagged-1. Whether further mechanisms of Notch activation exist and other Notch receptors might be involved is unclear. Microarray data indicated that Notch3 transcript levels are significantly up-regulated in primary and metastatic CRC samples compared to normal mucosa. Moreover, Notch3 protein was expressed at strong/moderate levels by 19.7% of 158...

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Authors: Serafin, V; Persano, L; Moserle, L; Esposito, G; Ghisi, M

• Journal: J Pathol
• Volume: 224
• Issue: 4
• Pages: 448-460
• Publication date: 2011-08-01
• DOI: 10.1002/path.2895
• EISSN: 1096-9896
• ISSN: 0022-3417
• Language: English
• Keywords: Membrane Proteins; Colorectal Neoplasms; Mice, Nude; Receptors, Notch; Intercellular Signaling Peptides and Proteins; Neoplasm Transplantation; Neoplasm Proteins; Signal Transduction; Gene Expression Regulation, Neoplastic; Tumor Cells, Cultured; Mice; Transplantation, Heterologous; Mice, SCID; Male; Humans; Cell Transformation, Neoplastic; Animals; Up-Regulation; Calcium-Binding Proteins