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Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation

Abstract:

High frequency deep brain stimulation of the thalamus can help ameliorate severe essential tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain stimulation might be improved in this condition. We started from the hypothesis that the effects of electrical stimulation on essential tremor may be phase dependent, and that, in particular, there are tremor phases at which stimuli preferentially lead to a reduction in the amplitude of tremor. The latter coul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awt239

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
More by this author
Institution:
University College London
Department:
Sobell Department of Motor Neuroscience and Movement Disorders
Role:
Author
More by this author
Institution:
University College London
Department:
Sobell Department of Motor Neuroscience and Movement Disorders
Role:
Author
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Contributors

National Institute of Health Research More from this funder
Medical Research Council More from this funder
Oxford Biomedical Research Centre More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
136
Issue:
10
Pages:
3062-3075
Publication date:
2013-10-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Subjects:
UUID:
uuid:6e3a9f88-8b8c-425c-badb-13ca6a5bc62b
Local pid:
ora:7782
Deposit date:
2014-02-03

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