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Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.

Abstract:

OBJECTIVES: To evaluate the clinical efficacy of a novel synthetic peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist, CLX-090717, in several in vitro cell culture systems and murine CIA, an experimental model of RA. METHODS: Peripheral blood monocytes purified by elutriation, and rheumatoid synovial cells isolated from clinical tissue were cultured with CLX-090717 and TNF-alpha release was measured. Molecular mechanism of action was analysed by western blotting and electr...

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Publication status:
Published

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Publisher copy:
10.1093/rheumatology/ken398

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Rheumatology (Oxford, England) More from this journal
Volume:
48
Issue:
1
Pages:
32-38
Publication date:
2009-01-01
DOI:
EISSN:
1462-0332
ISSN:
1462-0324

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